This book provides a comprehensive exploration of how information technology drives transformation, competitiveness, and sustainability in organizations worldwide. Chapter 1 examines the disruptive impact of digital transformation on companies, competition, and careers across local and global contexts. Chapters 2 through 4 introduce the foundations of information systems, IT infrastructure, cloud services, data management, governance, networks, the Internet of Things (IoT), and edge computing. Data privacy and cybersecurity challenges are addressed in Chapter 5, while Chapter 6 delves into business intelligence, data science, and advanced analytics as tools for decision-making. Chapters 7 and 8 explore the strategic role of social media, semantic web technologies, omnichannel retailing, e-commerce, and mobile commerce. Functional and enterprise-wide systems are detailed in Chapters 9 and 10, highlighting their contributions to operational efficiency and integration. Chapter 11 investigates emerging technologies including artificial intelligence, robotics, and quantum computing. Strategic management of IT, sourcing, and technology trends are discussed in Chapter 12, followed by systems development, IT service management, and project, program, and portfolio management in Chapter 13. Finally, Chapter 14 emphasizes IT ethics and sustainability, underscoring the need for responsible technology use to balance growth, social responsibility, and environmental stewardship. With its holistic approach, the book equips students, researchers, practitioners, and decision-makers with the knowledge to leverage IT for performance enhancement, sustainable growth, and global competitiveness